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PARACETAMOL FORMULATION
- Principle: Elixirs are clear, flavoured hydroalcoholic prepa- medicament, pleasantly flavoured usually yattractively coloured ration intended for oral use. They contain one or more containing high proportion of alcohol or sucrose along with some suitable antimicrobial agent. The alcoholic content in elixir vary from 5-40%. In general they are more stable than mixture as sufficient alcohol is added to maintain the drug in the solution.
- Elixirs are of two types
- 1. Non-medicated elixirs: They are used purely as diluting agents or solvents for drugs containing approximately 25% alcohol e.g. Simple elixirs is alcoholic elixirs or low alcohol elixirs (containing 7-10% alcohol) High alcoholic elixirs (containing 60-75% alcohol)
- 2. Medicated elixirs: Elixirs containing therapeutically active compounds are known as medicated elixirs e.g. Phenobarbital elixirs U S P, Dexa-methasone elixirs USP Chloropheniramine maleate elixirs.
- Procedure:
- 1. Mix ethanol (96%), propylene glycol and choloroform spirit and make a mixture.
- 2. Dissolve paracetamol and shake it, add other additives.
- 3. Finally sufficient amount of glycerin to produce 1000 ml.
- category: Antipyretic.
- Storage: Preserve in a well closed container, protect from light
- Uses: Analgesic and Antipyretic, used to bring down the
- elevated temperature.
- FORMULA IS IN PDF.